2. Academic Validation
  3. Synthesis and biological evaluation of novel taxoids designed for targeted delivery to tumors

Synthesis and biological evaluation of novel taxoids designed for targeted delivery to tumors

  • Bioorg Med Chem Lett. 2004 Dec 6;14(23):5885-8. doi: 10.1016/j.bmcl.2004.09.025.
Erkan Baloglu 1,  Michael L Miller,  Elizabeth E Roller,  Emily E Cavanagh,  Barbara A Leece,  Victor S Goldmacher,  Ravi V J Chari
Affiliations

Affiliation

  • 1 ImmunoGen, Inc., 128 Sidney Street, Cambridge, MA 02139, USA. erkan.baloglu@immunogen.com
PMID: 15501062 DOI: 10.1016/j.bmcl.2004.09.025
Abstract

The use of drug-antibody conjugates affords a method for the targeted delivery of Anticancer drugs specifically to Cancer cells. Monoclonal Antibodies alone usually do not possess high therapeutic efficacy, however, they are capable of targeting tumor markers selectively. We have prepared taxoids with significantly higher cytotoxicity than paclitaxel and docetaxel. These taxoids now meet the high potency required for use in a targeted-delivery approach using monoclonal Antibodies. The synthesis and biological evaluation of these taxoids are reported.

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