2. Academic Validation
  3. Cytotoxic activity of some natural and synthetic guaianolides

Cytotoxic activity of some natural and synthetic guaianolides

  • J Nat Prod. 2005 Jul;68(7):1042-6. doi: 10.1021/np0500575.
Maurizio Bruno 1,  Sergio Rosselli,  Antonella Maggio,  Rosa Angela Raccuglia,  Kenneth F Bastow,  Kuo-Hsiung Lee
Affiliations

Affiliation

  • 1 Dipartimento di Chimica Organica, Università di Palermo, Viale delle Scienze, 90128 Palermo, Italy. bruno@dicpm.unipa.it
PMID: 16038545 DOI: 10.1021/np0500575
Abstract

Several natural guaianolides and synthetic derivatives of repin (1) were tested and found to be active against tumor cell replication. Repin (1) and both mono- and di-halohydrin analogues (2, 7-9, 11, 12) showed significant antitumor potency. A more effective compound (17) was obtained by esterificating repin with the paclitaxel side chain.

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