2. Academic Validation
  3. Aspirochlorine class compounds from Aspergillus flavus inhibit azole-resistant Candida albicans

Aspirochlorine class compounds from Aspergillus flavus inhibit azole-resistant Candida albicans

  • J Nat Prod. 2005 Aug;68(8):1300-2. doi: 10.1021/np050141k.
Paul Klausmeyer 1,  Thomas G McCloud,  Kenneth D Tucker,  John H Cardellina 2nd,  Robert H Shoemaker
Affiliations

Affiliation

  • 1 Natural Products Support Group, SAIC-Frederick, Inc., Bldg 431, FCRDC, Frederick, Maryland 21702-1201, USA.
PMID: 16124785 DOI: 10.1021/np050141k
Abstract

Dereplication of the Antifungal extracts of Aspergillus flavus indicated that the primary Antifungal compound present was the known aspirochlorine (1). Preparative isolation work resulted in the identification of the new compounds tetrathioaspirochlorine (2) and cyclo(D-N-methyl-Leu-L-Trp) (3).

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