2. Academic Validation
  3. Synthesis and biological evaluation of methoxylated analogs of the newer generation taxoids IDN5109 and IDN5390

Synthesis and biological evaluation of methoxylated analogs of the newer generation taxoids IDN5109 and IDN5390

  • Bioorg Med Chem Lett. 2005 Dec 1;15(23):5182-6. doi: 10.1016/j.bmcl.2005.08.066.
Luciano Barboni 1,  Roberto Ballini,  Guido Giarlo,  Giovanni Appendino,  Gabriele Fontana,  Ezio Bombardelli
Affiliations

Affiliation

  • 1 Dipartimento di Scienze Chimiche, Università di Camerino, Via S. Agostino 1, 62032 Camerino (MC), Italy. luciano.barboni@unicam.it
PMID: 16183281 DOI: 10.1016/j.bmcl.2005.08.066
Abstract

Starting from 10-deacetylbaccatin III (7), the 2-debenzoyl-2-m-methoxybenzoyl analogs of the newer generation taxoids IDN5109 (3) and IDN5390 (4) were synthesized. The biological evaluation of these compounds (5 and 6, respectively) showed a general increase of cytotoxicity, as observed in first-generation Anticancer taxanes.

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