2. Academic Validation
  3. Privileged structure-based quinazolinone natural product-templated libraries: identification of novel tubulin polymerization inhibitors

Privileged structure-based quinazolinone natural product-templated libraries: identification of novel tubulin polymerization inhibitors

  • Bioorg Med Chem Lett. 2006 Feb;16(3):686-90. doi: 10.1016/j.bmcl.2005.10.022.
Ji-Feng Liu 1,  Christopher J Wilson,  Ping Ye,  Kevin Sprague,  Katie Sargent,  Ying Si,  Galina Beletsky,  Daniel Yohannes,  Shi-Chung Ng
Affiliations

Affiliation

  • 1 ArQule, Inc., 19 Presidential Way, Woburn, MA 01801, USA. jliu@arqule.com
PMID: 16257201 DOI: 10.1016/j.bmcl.2005.10.022
Abstract

A focused quinazolinone natural product-templated library was designed and synthesized. Compounds from this privileged structure-based library were identified as antimitotic agents acting through destabilization of tubulin polymerization. The results suggested that 2 could be a privileged substructure.

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