2. Academic Validation
  3. Rapid synthesis of triazole-modified resveratrol analogues via click chemistry

Rapid synthesis of triazole-modified resveratrol analogues via click chemistry

  • J Med Chem. 2006 Jan 26;49(2):467-70. doi: 10.1021/jm051118z.
Francesca Pagliai 1,  Tracey Pirali,  Erika Del Grosso,  Riccardo Di Brisco,  Gian Cesare Tron,  Giovanni Sorba,  Armando A Genazzani
Affiliations

Affiliation

  • 1 Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, Università degli Studi del Piemonte Orientale A. Avogadro, 28100 Novara, Italy.
PMID: 16420033 DOI: 10.1021/jm051118z
Abstract

Resveratrol is a phytoalexin able to display an array of biological activities. We decided to replace the double bond with a triazole ring using the archetypical click reaction: the Huisgen [3 + 2] cycloaddition. Seventy-two triazole derivatives were synthesized via a parallel combinatorial approach. Preliminary data suggest that this procedure can lead to the synthesis of compounds that display some, but not all, of resveratrol's actions with increased potency.

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