2. Academic Validation
  3. (+)-agelasine D: improved synthesis and evaluation of antibacterial and cytotoxic activities

(+)-agelasine D: improved synthesis and evaluation of antibacterial and cytotoxic activities

  • J Nat Prod. 2006 Mar;69(3):381-6. doi: 10.1021/np050424c.
Anders Vik 1,  Erik Hedner,  Colin Charnock,  Orjan Samuelsen,  Rolf Larsson,  Lise-Lotte Gundersen,  Lars Bohlin
Affiliations

Affiliation

  • 1 Department of Chemistry, University of Oslo, Norway.
PMID: 16562840 DOI: 10.1021/np050424c
Abstract

An improved synthesis of (+)-agelasine D (10) from (+)-manool is reported together with cytotoxic and Antibacterial data for agelasine D and structurally close synthetic analogues. These compounds display a broad spectrum of Antibacterial activities including effects on M. tuberculosis and Gram-positive and Gram-negative bacteria (both aerobes and anaerobes). They exhibit profound cytotoxic activity against several Cancer cells, including a multidrug-resistant cell line. (+)-Agelasine D (10) has been isolated earlier from a marine Sponge (Agelas sp.).

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