2. Academic Validation
  3. Rautandiols A and B, pterocarpans and cytotoxic constituents from Neorautanenia mitis

Rautandiols A and B, pterocarpans and cytotoxic constituents from Neorautanenia mitis

  • J Nat Prod. 2006 Mar;69(3):397-9. doi: 10.1021/np058070c.
Yojiro Sakurai 1,  Nobuko Sakurai,  Masahiko Taniguchi,  Yuka Nakanishi,  Kenneth F Bastow,  Xihong Wang,  Gordon M Cragg,  Kuo-Hsiung Lee
Affiliations

Affiliation

  • 1 Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill, 27599, USA.
PMID: 16562843 DOI: 10.1021/np058070c
Abstract

As part of a study on potential antitumor agents from rainforest Plants, two new pterocarpans, rautandiol A (1) and rautandiol B (2), together with eight known compounds, were isolated from Neorautanenia mitis. Among the compounds isolated, rotenone (3) and 12-hydroxyrotenone (4) showed significant cytotoxic activity with IC(50) values of 0.008-0.010 and 0.04-0.06 microg/mL against MCF-7 and A-549 cells, respectively.

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