2. Academic Validation
  3. Antimalarial activity of a new family of analogues of manzamine A

Antimalarial activity of a new family of analogues of manzamine A

  • Org Lett. 2006 Jun 8;8(12):2591-4. doi: 10.1021/ol060848d.
Jeffrey D Winkler 1,  Allyn T Londregan,  Mark T Hamann
Affiliations

Affiliation

  • 1 Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA. winkler@sas.upenn.edu
PMID: 16737321 DOI: 10.1021/ol060848d
Abstract

Manzamine A represents an important lead structure for the development of novel antimalarial chemotherapies. The synthesis and biological evaluation of a group of simplified analogues of manzamine A, which were designed to examine the roles of the A and D rings and of both the relative stereochemistry and the orientation of the beta-carboline heterocycle on the antimalarial activity of manzamine A, are described. [structure: see text]

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