2. PI3K/Akt/mTOR Stem Cell/Wnt Cell Cycle/DNA Damage Anti-infection Membrane Transporter/Ion Channel Autophagy
  3. GSK-3 CDK Parasite Proton Pump HSV Autophagy
  4. Manzamine A hydrochloride

Manzamine A hydrochloride  (Synonyms: Keramamine A hydrochloride)

目录号: HY-117025A 纯度: 99.66%
COA 产品使用指南

摩尔计算器

Manzamine A hydrochloride 是一种具有口服活性的 β-carboline 生物碱，抑制 GSK-3β 和 CDK-5 的 IC50 值为 10.2 μM 和 1.5 μM。Manzamine A hydrochloride 靶向胰腺癌细胞的 vacuolar ATPases 并抑制自噬 (autophagy)。Manzamine A hydrochloride 具有抗疟和抗癌活性。Manzamine A hydrochloride 对 HSV-1 具有较强的活性。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Manzamine A hydrochloride Chemical Structure

Manzamine A hydrochloride Chemical Structure

CAS No. : 104264-80-4

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥2500
In-stock
5 mg 现货 询价
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Manzamine A hydrochloride:

Manzamine A hydrochloride 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

Cell Viability Assay
Proliferation Assay

    Manzamine A hydrochloride purchased from MCE. Usage Cited in: Mar Drugs. 2023, 21(3), 151.

    Manzamine A (MA) shows a long-term ability to inhibit both MCF-7 and MDA-MB-231 cells growth. The MA (0, 2, 4 μM; 24 h)-treated cells are seeded in 6-well plates and then cultured for 2 weeks.

    Manzamine A hydrochloride purchased from MCE. Usage Cited in: Mar Drugs. 2023, 21(3), 151.

    Manzamine A (MA; 0, 0.5, 1, 2, 4, 8 μM; 24 h) shows cytotoxic effects on MDA-MB-231 and MCF-7 cells but is non-toxic to normal breast epithelial MCF-10A cells in a dose-dependent manner.

    查看 GSK-3 亚型特异性产品:

    查看所有亚型
    GSK-3 GSK-3α GSK-3β

    查看 CDK 亚型特异性产品:

    查看所有亚型
    CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

    查看 Parasite 亚型特异性产品:

    查看所有亚型
    Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

    查看 HSV 亚型特异性产品:

    查看所有亚型
    HSV-1 HSV-2 HSV

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Manzamine A hydrochloride, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC50s of 10.2 μM and 1.5 μM, respectively. Manzamine A hydrochloride targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A hydrochloride has antimalarial and anticancer activities. Manzamine A hydrochloride also shows potent activity against HSV-1[1][2][3][4].

    IC50 & Target[1][2][3]

    GSK-3β

    10.2 μM (IC50)

    Plasmodium

     

    CDK5

    1.5 μM (IC50)

    vacuolar ATPases

     

    Malaria

     

    HSV-1

     

    体外研究
    (In Vitro)

    Manzamine A (5-50 µM, 18 h) hydrochloride decreases tau phosphorylation, measured with ELISA[1].
    Manzamine A (10 µM) hydrochloride inhibits yeast S. cerevisiae growth by 30%[2].
    Manzamine A hydrochloride displays a few enlarged vacuoles in yeast[2].
    Manzamine A (2.5-10 µM, 24 h) hydrochloride increases acidity in pancreatic cancer cells and non-malignant Vero cells[2].
    Manzamine A (1 µM, 24 h) hydrochloride inhibits HSV-1 infection in SIRC cells[4].
    Manzamine A hydrochloride shows antimalarial activity with an IC50 of 8.0 nM (D6 clone) and 11 nM (W2 clone)[5].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Manzamine A hydrochloride 相关抗体:

    Cell Viability Assay[4]

    Cell Line: SIRC cell
    Concentration: 0.1, 0.5, 1, 2, 3, 5, and 10 µM
    Incubation Time: 72 h
    Result: Inhibited SIRC cell viability with an IC50 of 5.6 µM.
    体内研究
    (In Vivo)

    Manzamine A (50 and 100 mol/kg, p.o. or i.p.) hydrochloride inhibits the growth of the rodent malaria parasite Plasmodium berghei in infected mice[6].
    Manzamine A (8 mg/kg, i.p., daily for 8 consecutive days) hydrochloride prolongs the survival of SW mice to 20 days[7].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Plasmodium berghei in infected mice[6]
    Dosage: 50 or 100 mol/kg
    Administration: Intraperitoneal injection (i.p.) or oral administration (p.o.)
    Result: Inhibited the growth of the rodent malaria parasite Plasmodium berghei. Prolonged the survival of highly parasitaemic mice.
    分子量

    585.22

    Formula

    C36H45ClN4O
    CAS 号
    性状

    固体

    颜色

    Light yellow to brown

    结构分类
    初始来源

    sponge
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    4°C, sealed storage, away from moisture and light

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    溶解性数据
    细胞实验： 

    DMSO 中的溶解度 : 5.88 mg/mL (10.05 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 1.7088 mL 8.5438 mL 17.0876 mL
    5 mM 0.3418 mL 1.7088 mL 3.4175 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    纯度 & 产品资料

    纯度: 99.66%

    COA (209 KB) RP-HPLC (256 KB)

    产品使用指南 (1538 KB)
    参考文献

    Manzamine A hydrochloride 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.7088 mL 8.5438 mL 17.0876 mL 42.7190 mL
    5 mM 0.3418 mL 1.7088 mL 3.4175 mL 8.5438 mL
    10 mM 0.1709 mL 0.8544 mL 1.7088 mL 4.2719 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Manzamine A104264-80-4Keramamine AGSK-3CDKParasiteProton PumpHSVAutophagyGlycogen synthase kinase-3Glycogen synthase kinase 3Cyclin dependent kinaseHerpes simplex virusmanzaminealkaloidAlzheimer'sdiseasepancreaticcancerantimalarialInhibitorinhibitorinhibit

    您最近查看的产品:

    Your information is safe with us. * Required Fields.

       产品名称：

    		  

    * 需求量：

    * 客户姓名：

    		 

    * Email：

    * 电话：

    		 

    * 公司或机构名称：

       留言给我们：

    Bulk Inquiry

    Inquiry Information

    产品名称：
    Manzamine A hydrochloride
    目录号：
    HY-117025A
    需求量：

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

       产品名称：

    		  

    * Lot #：

    * 客户姓名：

    		 

    * Email：

       电话：

    		 

    * 部门：

    * 公司或机构名称：

    		 

       留言给我们：

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.

    嗨！很高兴为您提供帮助！

    尊敬的 MCE 客户您好，
    请您选择所在区域，我们将转接对应客服为您服务！

    热门区域

    A

    B

    C

    F

    G

    H

    J

    L

    N

    Q

    S

    T

    X

    Y

    Z

    热 A B C F G H J L N Q S T X Y Z