2. Academic Validation
  3. Taraxasterane- and ursane-type triterpenes from Nerium oleander and their biological activities

Taraxasterane- and ursane-type triterpenes from Nerium oleander and their biological activities

  • J Nat Prod. 2006 Aug;69(8):1164-7. doi: 10.1021/np0680073.
Ming Zhao 1,  Shujun Zhang,  Liwei Fu,  Na Li,  Jiao Bai,  Junichi Sakai,  Liyan Wang,  Wanxia Tang,  Toshiaki Hasegawa,  Hirotsugu Ogura,  Takao Kataoka,  Seiko Oka,  Miwa Kiuch,  Katutoshi Hirose,  Masayoshi Ando
Affiliations

Affiliation

  • 1 Graduate School of Science and Technology, Niigata University, Ikarashi, 2-8050, Niigata 950-2181, Japan.
PMID: 16933868 DOI: 10.1021/np0680073
Abstract

Two new taraxasterane-type Triterpenes, 20beta,28-epoxy-28alpha-methoxytaraxasteran-3beta-ol (1) and 20beta,28-epoxytaraxaster-21-en-3beta-ol (2), were isolated from an ethyl acetate extract of the leaves of Nerium oleander, together with ursane-type Triterpenes, 28-nor-urs-12-ene-3beta,17beta-diol (3) and 3beta-hydroxyurs-12-en-28-aldehyde (4). The structures of 1 and 2 were established on the basis of their spectroscopic data. Anti-inflammatory activity of 1-4 was examined on the basis of inhibitory activity against the induction of intercellular adhesion molecule-1 (ICAM-1). Cytotoxic activity of 1-4 was evaluated against four human cell lines, A-549, WI-38, VA-13, and HepG2 cells.

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