2. Academic Validation
  3. Paecilaminol, a new NADH-fumarate reductase inhibitor, produced by Paecilomyces sp. FKI-0550

Paecilaminol, a new NADH-fumarate reductase inhibitor, produced by Paecilomyces sp. FKI-0550

  • J Antibiot (Tokyo). 2006 Sep;59(9):591-6. doi: 10.1038/ja.2006.79.
Hideaki Ui 1,  Kazuro Shiomi,  Hideaki Suzuki,  Hiroko Hatano,  Hiromi Morimoto,  Yuichi Yamaguchi,  Rokuro Masuma,  Kimitoshi Sakamoto,  Kiyoshi Kita,  Hideto Miyoshi,  Hiroshi Tomoda,  Haruo Tanaka,  Satoshi Omura
Affiliations

Affiliation

  • 1 Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, Japan.
PMID: 17136891 DOI: 10.1038/ja.2006.79
Abstract

A new NADH-fumarate reductase inhibitor, paecilaminol, was isolated from the cultured broth of a fungus Paecilomyces sp. FKI-0550. It is an amino alcohol compound, the structure being established as 2-amino-14,16-dimethyl-3-octadecanol. Paecilaminol exhibited an IC50 value of 5.1 microM against Ascaris suum NADH-fumarate reductase.

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