2. Academic Validation
  3. Synthesis and bioactivity of 4-alkyl(aryl)thioquinazoline derivatives

Synthesis and bioactivity of 4-alkyl(aryl)thioquinazoline derivatives

  • Bioorg Med Chem Lett. 2007 Apr 15;17(8):2193-6. doi: 10.1016/j.bmcl.2007.01.101.
Song Yang 1,  Zhi Li,  Linhong Jin,  Baoan Song,  Gang Liu,  Jiang Chen,  Zhuo Chen,  Deyu Hu,  Wei Xue,  Ruiqing Xu
Affiliations

Affiliation

  • 1 Center for Research and Development of Fine Chemicals, Key Laboratory of Green Pesticide and Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, PR China.
PMID: 17317179 DOI: 10.1016/j.bmcl.2007.01.101
Abstract

Some S'-substituted 4-alkyl(aryl)thioquinazoline derivatives were synthesized through thioetherification reaction of 4-chloroquinazolines 2 and thiol compounds 1 refluxed in acetone in the presence of K(2)CO(3). Their structures were verified by elemental analysis, IR, (1)H NMR, and (13)C NMR. The compounds were evaluated for their anti-proliferative activities against some Cancer cells in vitro by MTT method. Among them, 3c, 3a, 3d, 3f, and 3l were highly effective against PC3 cells and 3a-3m showed weak activities against Bcap37 and BGC823 cells. The IC(50) value of 3c, 3a, 3d, 3f, and3l against PC3 cell was 1.8, 5.6, 8.1, 8.7, and 8.9 microM, respectively.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z