2. Academic Validation
  3. (Aryloxyacetylamino)benzoic acid analogues: A new class of hypoxia-inducible factor-1 inhibitors

(Aryloxyacetylamino)benzoic acid analogues: A new class of hypoxia-inducible factor-1 inhibitors

  • J Med Chem. 2007 Apr 5;50(7):1675-84. doi: 10.1021/jm0610292.
Kyeong Lee 1,  Jeong Hyung Lee,  Shanthaveerappa K Boovanahalli,  Yinglan Jin,  Mijeoung Lee,  Xuejun Jin,  Jin Hwan Kim,  Young-Soo Hong,  Jung Joon Lee
Affiliations

Affiliation

  • 1 Molecular Cancer Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea, 305-806.
PMID: 17328532 DOI: 10.1021/jm0610292
Abstract

Structural modification of a compound discovered during screening using an HRE-dependent reporter assay has revealed a novel class of HIF-1 inhibitors, which potently inhibit the HIF-1alpha protein accumulation and its target gene expression under hypoxic conditions in human hepatocellular carcinoma Hep3B cells.

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