2. Academic Validation
  3. Synthesis and biological evaluation of nucleoside analogues having 6-chloropurine as anti-SARS-CoV agents

Synthesis and biological evaluation of nucleoside analogues having 6-chloropurine as anti-SARS-CoV agents

  • Bioorg Med Chem Lett. 2007 May 1;17(9):2470-3. doi: 10.1016/j.bmcl.2007.02.026.
Masahiro Ikejiri 1,  Masayuki Saijo,  Shigeru Morikawa,  Shuetsu Fukushi,  Tetsuya Mizutani,  Ichiro Kurane,  Tokumi Maruyama
Affiliations

Affiliation

  • 1 Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, 1314-1 Shido, Sanuki, Kagawa 769-2193, Japan.
PMID: 17336519 DOI: 10.1016/j.bmcl.2007.02.026
Abstract

Nucleoside analogues that have 6-chloropurine as the nucleobase were synthesized and evaluated for anti-SARS-CoV activity by plaque reduction and yield reduction assays in order to develop novel anti-SARS-CoV agents. Among these analogues, two compounds, namely, 1 and 11, exhibited promising anti-SARS-CoV activity that was comparable to those of mizoribine and ribavirin, which are known anti-SARS-CoV agents. Moreover, we observed several SAR trends such as the Antiviral effects of the 6-chloropurine moiety, unprotected 5'-hydroxyl group and benzoylated 5'-hydroxyl group.

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