2. Academic Validation
  3. Synthesis, biological evaluations, and tubulin binding poses of C-2alpha sulfur linked taxol analogues

Synthesis, biological evaluations, and tubulin binding poses of C-2alpha sulfur linked taxol analogues

  • Bioorg Med Chem Lett. 2007 Jun 1;17(11):3191-4. doi: 10.1016/j.bmcl.2007.03.026.
Lei Wang 1,  Ana A Alcaraz,  Ruth Matesanz,  Chun-Gang Yang,  Isabel Barasoain,  J Fernando Díaz,  Ye-Zhi Li,  James P Snyder,  Wei-Shuo Fang
Affiliations

Affiliation

  • 1 Institute of Materia Medica, Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing 100050, PR China.
PMID: 17395465 DOI: 10.1016/j.bmcl.2007.03.026
Abstract

In combination with chemical modifications, bioassays, and computational simulation techniques, C-2 benzoylthio, and benzylthio taxoids were synthesized, biologically evaluated, and their binding conformations rationalized, in order to probe the interaction of taxane molecule with beta-tubulin.

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