2. Academic Validation
  3. Inhibition of pro-inflammatory enzymes by inuviscolide, a sesquiterpene lactone from Inula viscosa

Inhibition of pro-inflammatory enzymes by inuviscolide, a sesquiterpene lactone from Inula viscosa

  • Fitoterapia. 2007 Jun;78(4):329-31. doi: 10.1016/j.fitote.2007.03.005.
Salvador Máñez 1,  Victoriano Hernández,  Rosa-María Giner,  José-Luis Ríos,  María Del Carmen Recio
Affiliations

Affiliation

  • 1 Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Avinguda Vicent Andrés Estellés s/n, 46100 Burjassot, Spain. manez@uv.es
PMID: 17490829 DOI: 10.1016/j.fitote.2007.03.005
Abstract

This work concerns the pharmacological activity of inuviscolide, a sesquiterpenoid from Inula viscosa. It exerts inhibitory effects on Elastase, cyclooxygenase 1 and secretory Phospholipase A(2). Furthermore, it reduces the skin leukocyte infiltration in a murine model of dermatitis induced by repeated application of 12-O-tetradecanoylphorbol 13-acetate.

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