2. Apoptosis
  3. Apoptosis
  4. Inuviscolide

Inuviscolide 是一种细胞凋亡 (apoptosis) 诱导剂。Inuviscolide 可以诱导人黑素瘤细胞系的 G2/M 期停滞。Inuviscolide 具有抗肿瘤和抗炎活性。

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Inuviscolide Chemical Structure

Inuviscolide Chemical Structure

CAS No. : 63109-30-8

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Inuviscolide 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Inuviscolide is an apoptosis inducer. Inuviscolide can induce of G2/M arrest in human melanoma cell lines. Inuviscolide exhibits antineoplastic and anti-inflammatory activities[1][2][3].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
RAW264.7 IC50
21.9 μM
Compound: 21
Antiinflammatory action in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production treated 30 mins before LPS challenge measured after 24 hrs by griess reaction
Antiinflammatory action in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production treated 30 mins before LPS challenge measured after 24 hrs by griess reaction
[PMID: 21894898]
RAW264.7 IC50
9.64 μM
Compound: 20
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins before LPS challenge measured 24 hrs after LPS challenge by Griess reaction method
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins before LPS challenge measured 24 hrs after LPS challenge by Griess reaction method
[PMID: 21924800]
体外研究
(In Vitro)

Inuviscolide (9-72 μM; 24 h) 抑制 SK-28，624 和 1363 黑色素瘤细胞的增殖，IC50 值分别为 37，41.1 和 39 μM[2]。
Inuviscolide (36-54 μM; 4-24 h) 导致 SK-28 细胞在 G2/M 期发生剂量依赖性积累[2]。
Inuviscolide (72 μM; 48 h) 导致约 70% 的 SK-28 细胞表现出早期凋亡标志物[2]。
Inuviscolide 在 100 μM 时抑制人白细胞弹性蛋白酶的释放 51%[1]。
Inuviscolide 抑制蜂毒分泌的 PLA2 (sPLA2)，IC50 值为 80.5 μM[1]。
Inuviscolide 在 50 μM 时抑制 COX-1 (40%)，而它对诱导型 COX-2 没有活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Inuviscolide 相关抗体:

Cell Proliferation Assay[2]

Cell Line: SK-28, 624 and 1363 melanoma cells
Concentration: 9-72 μM
Incubation Time: 24 hours
Result: Resulted in a dose-dependent inhibition of cellular proliferation, with no significant changes between the three cell lines.
体内研究
(In Vivo)

Inuviscolide 减少了反复应用 12-O-tetradecanoylphorbol 13-acetate 诱导的皮炎小鼠皮肤白细胞浸润[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

248.32

Formula

C15H20O3
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Inuviscolide 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Inuviscolide63109-30-8ApoptosisG2/Mmelanoma cellantineoplasticanti-inflammatoryInhibitorinhibitorinhibit

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