2. Academic Validation
  3. Synthesis and structure-activity relationship of novel indene N-oxide derivatives as potent peroxisome proliferator activated receptor gamma (PPARgamma) agonists

Synthesis and structure-activity relationship of novel indene N-oxide derivatives as potent peroxisome proliferator activated receptor gamma (PPARgamma) agonists

  • Bioorg Med Chem Lett. 2007 Sep 15;17(18):5239-44. doi: 10.1016/j.bmcl.2007.06.073.
Jin Hee Ahn 1,  Mi Sik Shin,  Sun Ho Jung,  Jin Ah Kim,  Hye Min Kim,  Se Hoan Kim,  Seung Kyu Kang,  Kwang Rok Kim,  Sang Dal Rhee,  Sung Dae Park,  Jae Mok Lee,  Jeong Hyung Lee,  Hyae Gyeong Cheon,  Sung Soo Kim
Affiliations

Affiliation

  • 1 Bioorganic Science Division, Korea Research Institute of Chemical Technology, Yuseong-Gu, Daejeon 305-600, Republic of Korea. jhahn@krict.re.kr
PMID: 17624777 DOI: 10.1016/j.bmcl.2007.06.073
Abstract

A series of novel indene N-oxide derivatives were prepared by various synthetic methods and evaluated for their ability to activate PPARgamma. The best PPARgamma agonist in this series was 9h, which showed an EC(50) value of 15 nM.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z