2. Academic Validation
  3. Synthesis and biological evaluation of cepharadiones A and B and related dioxoaporphines

Synthesis and biological evaluation of cepharadiones A and B and related dioxoaporphines

  • Bioorg Med Chem. 2007 Sep 15;15(18):6119-25. doi: 10.1016/j.bmc.2007.06.035.
Mark A Elban 1,  Jean C Chapuis,  Mei Li,  Sidney M Hecht
Affiliations

Affiliation

  • 1 Departments of Chemistry and Biology, University of Virginia, Charlottesville, VA 22904, USA.
PMID: 17624787 DOI: 10.1016/j.bmc.2007.06.035
Abstract

Described herein is the first total synthesis and structural confirmation of cepharadione A, a naturally occurring DNA damaging agent. Also reported is the synthesis of cepharadione B, a closely related natural product, as well as the biological evaluation of both Natural Products. Finally, the preparation and biological evaluation of novel dioxoaporphine analogues is described.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z