2. Academic Validation
  3. Antimicrobial activity of omiganan pentahydrochloride against contemporary fungal pathogens responsible for catheter-associated infections

Antimicrobial activity of omiganan pentahydrochloride against contemporary fungal pathogens responsible for catheter-associated infections

  • Antimicrob Agents Chemother. 2008 Mar;52(3):1187-9. doi: 10.1128/AAC.01475-07.
Thomas R Fritsche 1,  Paul R Rhomberg,  Helio S Sader,  Ronald N Jones
Affiliations

Affiliation

  • 1 JMI Laboratories, 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317, USA. thomas-fritsche@jmilabs.com
PMID: 18180345 DOI: 10.1128/AAC.01475-07
Abstract

Omiganan, a bactericidal and fungicidal cationic peptide being developed as a topical gel for prevention of catheter-associated infections, inhibited commonly occurring Fungal pathogens including Candida spp. (106 isolates) at <or=256 microg/ml and molds (including 10 Aspergillus isolates) at <or=1,024 microg/ml. All fungi were inhibited by omiganan at concentrations well below the 1% (10,000 microg/ml) clinical formulation, including species with reduced susceptibility to azoles and echinocandins.

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