2. Academic Validation
  3. Discovery of novel FMS kinase inhibitors as anti-inflammatory agents

Discovery of novel FMS kinase inhibitors as anti-inflammatory agents

  • Bioorg Med Chem Lett. 2008 Mar 1;18(5):1642-8. doi: 10.1016/j.bmcl.2008.01.059.
Carl R Illig 1,  Jinsheng Chen,  Mark J Wall,  Kenneth J Wilson,  Shelley K Ballentine,  M Jonathan Rudolph,  Renee L DesJarlais,  Yanmin Chen,  Carsten Schubert,  Ioanna Petrounia,  Carl S Crysler,  Christopher J Molloy,  Margery A Chaikin,  Carl L Manthey,  Mark R Player,  Bruce E Tomczuk,  Sanath K Meegalla
Affiliations

Affiliation

  • 1 Johnson & Johnson Pharmaceutical Research & Development, Welsh & McKean Roads, Spring House, PA 19477, USA.
PMID: 18242992 DOI: 10.1016/j.bmcl.2008.01.059
Abstract

The optimization of the arylamide lead 2 resulted in identification of a highly potent series of 2,4-disubstituted arylamides. Compound 8 (FMS kinase IC(50)=0.0008 microM) served as a proof-of-concept candidate in a collagen-induced model of arthritis in mice.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z