2. Academic Validation
  3. Indole- and indolizine-glyoxylamides displaying cytotoxicity against multidrug resistant cancer cell lines

Indole- and indolizine-glyoxylamides displaying cytotoxicity against multidrug resistant cancer cell lines

  • Bioorg Med Chem Lett. 2008 Mar 15;18(6):1784-7. doi: 10.1016/j.bmcl.2008.02.029.
David A James 1,  Keizo Koya,  Hao Li,  Guiqing Liang,  Zhiqiang Xia,  Weiwen Ying,  Yaming Wu,  Lijun Sun
Affiliations

Affiliation

  • 1 Synta Pharmaceuticals, 45 Hartwell Ave, Lexington, MA 02421, USA. djames@syntapharma.com
PMID: 18308566 DOI: 10.1016/j.bmcl.2008.02.029
Abstract

We report herein the SAR studies of a series of indole- and indolizine-glyoxylamides that demonstrate substantial in vitro anti-proliferative activities against Cancer cell lines, including multidrug resistance (MDR) phenotypes. The in vitro cytotoxic effects have been demonstrated across a wide array of tumor types of various origins (e.g., breast, colon, uterine).

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