2. Academic Validation
  3. Synthesis of indirubin-N'-glycosides and their anti-proliferative activity against human cancer cell lines

Synthesis of indirubin-N'-glycosides and their anti-proliferative activity against human cancer cell lines

  • Bioorg Med Chem. 2008 May 15;16(10):5570-83. doi: 10.1016/j.bmc.2008.04.003.
Stefanie Libnow 1,  Karen Methling,  Martin Hein,  Dirk Michalik,  Manuela Harms,  Kristian Wende,  Anke Flemming,  Martin Köckerling,  Helmut Reinke,  Patrick J Bednarski,  Michael Lalk,  Peter Langer
Affiliations

Affiliation

  • 1 Institut für Chemie der Universität Rostock, Germany.
PMID: 18434163 DOI: 10.1016/j.bmc.2008.04.003
Abstract

The first indirubin-N'-glycosides were prepared based on reactions of isatin-N'-glycosides with indoxyls. The products show a significant anti-proliferative activity against various human Cancer cell lines. Good results were observed for an indirubin-N'-mannoside which was shown to have medium to high anti-proliferative activity against all investigated cell lines. The highest activities and selectivities against the MCF-7 breast Cancer cell line were observed for indirubin-N'-rhamnosides.

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