2. Academic Validation
  3. Selective inhibitory effects of hybrid liposomes on the growth of HIV type 1-infected cells in vitro

Selective inhibitory effects of hybrid liposomes on the growth of HIV type 1-infected cells in vitro

  • Bioorg Med Chem Lett. 2008 Aug 15;18(16):4578-80. doi: 10.1016/j.bmcl.2008.07.030.
Ryuichi Ueoka 1,  Yuji Komizu,  Yoko Matsumoto,  Yu Zhong,  Ritsuko Tanaka,  Naoki Yamamoto
Affiliations

Affiliation

  • 1 Graduate Course of Applied Life Science, Sojo University, 4-22-1 Ikeda, Kumamoto 860-0082, Japan. ueoka@life.sojo-u.ac.jp
PMID: 18672367 DOI: 10.1016/j.bmcl.2008.07.030
Abstract

A good correlation between fifty-percent inhibitory concentration (IC(50)) of hybrid liposomes (HL) composed of dimyristoylphosphatidylcholine and polyoxyethylene(n) dodecyl ether on the growth of MOLT-4/IIIB cells (MOLT-4 cells chronically infected with human immunodeficiency virus (HIV)) and the membrane fluidity of HL was obtained. Furthermore, the huge enhancement of virus production was observed in the latently HIV-infected (J(22)-HL-60) cells after the treatment with HL.

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