2. Academic Validation
  3. Design, synthesis, and biological evaluation of new mitonafide derivatives as potential antitumor drugs

Design, synthesis, and biological evaluation of new mitonafide derivatives as potential antitumor drugs

  • Bioorg Med Chem. 2008 Sep 15;16(18):8440-6. doi: 10.1016/j.bmc.2008.08.027.
Ippolito Antonini 1,  Rosaria Volpini,  Diego Dal Ben,  Catia Lambertucci,  Gloria Cristalli
Affiliations

Affiliation

  • 1 Department of Chemical Sciences, University of Camerino, Via S. Agostino 1, 62032 Camerino, Italy. ippolito.antonini@unicam.it
PMID: 18774722 DOI: 10.1016/j.bmc.2008.08.027
Abstract

A series of potential DNA-binding antitumor agents, 2-[omega-(alkylamino)alkyl]-6-{[omega-(alkylamino)alkyl]amino}-1H-benzo[de]isoquinolin-1,3(2H)-diones and 1,7-bis{6-[(omega-(dimethylamino)alkyl)amino]-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl}-4-methyl-4-azaheptanes, have been prepared as mitonafide derivatives. Their DNA-binding ability and cytotoxic activity have been evaluated. Some of the target compounds have shown high DNA affinity as well as relevant cytotoxic properties.

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