2. Academic Validation
  3. Whole structure-activity relationships of the fat-accumulation inhibitor (-)-ternatin: recognition of the importance of each amino acid residue

Whole structure-activity relationships of the fat-accumulation inhibitor (-)-ternatin: recognition of the importance of each amino acid residue

  • J Med Chem. 2008 Oct 9;51(19):5912-4. doi: 10.1021/jm800741n.
Kenichiro Shimokawa 1,  Yoshiaki Iwase,  Ryoka Miwa,  Kaoru Yamada,  Daisuke Uemura
Affiliations

Affiliation

  • 1 Department of Chemistry, Graduate School of Science, Nagoya University, Furo-cho, Chikusa, Nagoya 464-8602, Japan.
PMID: 18798610 DOI: 10.1021/jm800741n
Abstract

A series of Ala and Aoc analogues of (-)-ternatin were prepared, and their bioactivities were assessed by a fat-accumulation inhibition assay using 3T3-L1 adipocytes, which led to the discovery of key structure-activity relationships (SAR).

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