2. Academic Validation
  3. Dihydropyrazolopyrimidine inhibitors of K(V)1.5 (I(Kur))

Dihydropyrazolopyrimidine inhibitors of K(V)1.5 (I(Kur))

  • Bioorg Med Chem Lett. 2008 Dec 15;18(24):6381-5. doi: 10.1016/j.bmcl.2008.10.099.
Wayne Vaccaro 1,  Tram Huynh,  John Lloyd,  Karnail Atwal,  Heather J Finlay,  Paul Levesque,  Mary Lee Conder,  Tonya Jenkins-West,  Hong Shi,  Lucy Sun
Affiliations

Affiliation

  • 1 Bristol-Myers Squibb, Route 206 & Provinceline Road, PO Box 4000, Princeton, NJ 08543-4000, USA. wayne.vaccaro@bms.com
PMID: 19004630 DOI: 10.1016/j.bmcl.2008.10.099
Abstract

A series of dihydropyrazolopyrimidine inhibitors of K(V)1.5 (I(Kur)) have been identified. The synthesis, structure-activity relationships and selectivity against several Other ion channels are described.

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