2. Academic Validation
  3. Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases

Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases

  • Bioorg Med Chem. 2009 Mar 15;17(6):2276-81. doi: 10.1016/j.bmc.2008.10.090.
Shugeng Cao 1,  Brian T Murphy,  Caleb Foster,  John S Lazo,  David G I Kingston
Affiliations

Affiliation

  • 1 Department of Chemistry, Virginia Polytechnic Institute and State University, 3111 Hahn Hall, M/C 0212, Blacksburg, VA 24061, USA.
PMID: 19028102 DOI: 10.1016/j.bmc.2008.10.090
Abstract

Some simplified adociaquinone B analogs and a series of 1,4-naphthoquinone derivatives were synthesized and tested against the three Enzymes Cdc25B, MKP-1, and MKP-3. Cdc25B and MKP-1 in particular are Enzymes overexpressed in human Cancer cells, and they represent potential molecular targets for novel Cancer chemotherapeutic treatments. A number of analogs exhibited significant inhibitory activity against these Enzymes, and the bioassay data in addition to structure-activity relationships of these compounds will be discussed.

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