2. Academic Validation
  3. Theileria apicoplast as a target for chemotherapy

Theileria apicoplast as a target for chemotherapy

  • Antimicrob Agents Chemother. 2009 Mar;53(3):1213-7. doi: 10.1128/AAC.00126-08.
Regina Lizundia 1,  Dirk Werling,  Gordon Langsley,  Stuart A Ralph
Affiliations

Affiliation

  • 1 Département Maladies Infectieuses, Laboratoire de Biologie Cellulaire Comparative des Apicomplexes, UMR 8104 CNRS/U567 INSERM, Hôpital Cochin-Bâtiment Gustave Roussy, Institut Cochin, Paris, France.
PMID: 19075064 DOI: 10.1128/AAC.00126-08
Abstract

Theileria parasites cause severe bovine disease and death in a large part of the world. These apicomplexan parasites possess a relic plastid (apicoplast), whose metabolic pathways include several promising drug targets. Putative inhibitors of these targets were screened, and we identified antiproliferative compounds that merit further characterization.

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