2. Academic Validation
  3. Cytotoxic spirostane-type saponins from the roots of Chlorophytum borivilianum

Cytotoxic spirostane-type saponins from the roots of Chlorophytum borivilianum

  • J Nat Prod. 2009 Jan;72(1):177-81. doi: 10.1021/np800559z.
Debabrata Acharya 1,  Anne-Claire Mitaine-Offer,  Nutan Kaushik,  Tomofumi Miyamoto,  Thomas Paululat,  Jean-François Mirjolet,  Olivier Duchamp,  Marie-Aleth Lacaille-Dubois
Affiliations

Affiliation

  • 1 Laboratoire de Pharmacognosie, Unite de Molecules d'Interet Biologique, UMIB UPRES-EA 3660, Faculte de Pharmacie, Universite de Bourgogne, 21079 Dijon Cedex, France.
PMID: 19128156 DOI: 10.1021/np800559z
Abstract

Four new spirostane-type saponins named borivilianosides E-H (1-4) were isolated from an ethanol extract of the roots of Chlorophytum borivilianum together with two known steroid saponins (5 and 6). The structures of 1-4 were elucidated using mainly 2D NMR spectroscopic techniques and mass spectrometry. The cytotoxicity of borivilianosides F (2), G (3), and H (4) and three known compounds was evaluated using two human colon Cancer cell lines (HT-29 and HCT 116).

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