2. Academic Validation
  3. Synthesis and biological evaluation of abietic acid derivatives

Synthesis and biological evaluation of abietic acid derivatives

  • Eur J Med Chem. 2009 Jun;44(6):2468-72. doi: 10.1016/j.ejmech.2009.01.014.
Miguel A González 1,  Julieth Correa-Royero,  Lee Agudelo,  Ana Mesa,  Liliana Betancur-Galvis
Affiliations

Affiliation

  • 1 Departamento de Química Orgánica, Universidad de Valencia, Dr. Moliner 50, E-46100 Burjassot, Valencia, Spain. miguel.a.gonzalez@uv.es
PMID: 19217699 DOI: 10.1016/j.ejmech.2009.01.014
Abstract

A series of C18-oxygenated derivatives of abietic acid were synthesized and evaluated for their cytotoxic, antimycotic, and Antiviral activities. In general, the introduction of an aldehyde group at C18 did improve the resultant bioactivity, while the presence of an acid or alcohol led to less active compounds.

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