1. Academic Validation
  2. Cytotoxic constituents of chinese propolis

Cytotoxic constituents of chinese propolis

  • J Nat Prod. 2009 Apr;72(4):799-801. doi: 10.1021/np900118z.
Na Sha 1 Shu-Hong Guan Zhi-Qiang Lu Guang-Tong Chen Hui-Lian Huang Fu-Bo Xie Qing-Xi Yue Xuan Liu De-An Guo
Affiliations

Affiliation

  • 1 Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhangjiang, Shanghai, People's Republic of China.
Abstract

A pair of new flavanol racemates (1a and 1b) and a new flavanol racemic mixture (2) were isolated from crude propolis from Henan Province, People's Republic of China. Also obtained were nine known compounds, including two Flavones, four Flavonols, two Flavanols, and isoferulic acid. Spectroscopic analysis was employed to assign the structures of these new compounds and the absolute configurations of 1a and 1b. Cytotoxicity of the isolated compounds against the HeLa human cervical carcinoma Cancer cell line was evaluated, with only compounds 1a, 1b, 2, and rhamnetin (3) being active.

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