2. Academic Validation
  3. Labdane diterpenoid glycosides from Alpinia densespicata and their nitric oxide inhibitory activities in macrophages

Labdane diterpenoid glycosides from Alpinia densespicata and their nitric oxide inhibitory activities in macrophages

  • J Nat Prod. 2009 Jun;72(6):1097-101. doi: 10.1021/np900019n.
Yu-Jen Kuo 1,  Ping-Chun Hsiao,  Li-Jie Zhang,  Ming-Der Wu,  Yu-Han Liang,  Hsiu-O Ho,  Yao-Haur Kuo
Affiliations

Affiliation

  • 1 National Research Institute of Chinese Medicine, Taipei, Taiwan, Republic of China.
PMID: 19555124 DOI: 10.1021/np900019n
Abstract

Four new labdane diterpene glycosides (1-4) named alpindenosides A, B, C, and D, two new norditerpene glycosides (5, 6) named noralpindenosides A and B, and three known flavonoid glycosides (7-9) have been isolated from the stems of Alpinia densespicata. Structural elucidation of compounds 1-6 was based on spectroscopic data. Compounds 1-9 all exhibited moderate NO inhibitory activities, whereas they were noncytotoxic at 20 microM against several human tumor cell lines.

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