2. Academic Validation
  3. Design, synthesis, enzyme inhibition, and tumor cell growth inhibition of 2-anilinobenzamide derivatives as SIRT1 inhibitors

Design, synthesis, enzyme inhibition, and tumor cell growth inhibition of 2-anilinobenzamide derivatives as SIRT1 inhibitors

  • Bioorg Med Chem. 2009 Aug 15;17(16):5900-5. doi: 10.1016/j.bmc.2009.07.001.
Takayoshi Suzuki 1,  Keiko Imai,  Erika Imai,  Shinsuke Iida,  Ryuzo Ueda,  Hiroki Tsumoto,  Hidehiko Nakagawa,  Naoki Miyata
Affiliations

Affiliation

  • 1 Nagoya City University, Tanabe-dori, Mizuho-ku, Aichi, Japan. suzuki@phar.nagoya-cu.ac.jp
PMID: 19616958 DOI: 10.1016/j.bmc.2009.07.001
Abstract

A series of 2-anilinobenzamide derivatives were designed, synthesized and evaluated for their SIRT1-inhibitory activity. Among these, compounds 3 and 5 inhibited SIRT1 activity in Enzyme assays and suppressed the growth of Daudi and HCT116 cells.

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