2. Academic Validation
  3. Synthesis and anticancer activity of novel 3,4-diarylthiazol-2(3H)-ones (imines)

Synthesis and anticancer activity of novel 3,4-diarylthiazol-2(3H)-ones (imines)

  • Bioorg Med Chem Lett. 2009 Oct 1;19(19):5661-4. doi: 10.1016/j.bmcl.2009.08.025.
Zong-Ying Liu 1,  Yue-Ming Wang,  Zhuo-Rong Li,  Jian-Dong Jiang,  David W Boykin
Affiliations

Affiliation

  • 1 Department of Chemistry, Georgia State University, Atlanta, GA 30303-3083, USA.
PMID: 19713108 DOI: 10.1016/j.bmcl.2009.08.025
Abstract

A series of 3,4-diarylthiazol-2(3H)-ones and three 3,4-diarylthiazol-2(3H)-imines were synthesized and evaluated for their cytotoxicity in a panel of human Cancer cell lines. Compounds 21 and 22 showed potential Anticancer activity against human CEM cells with IC50 values of 0.12 and 0.24microM, respectively.

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