2. Academic Validation
  3. Cytotoxic acacic acid glycosides from the roots of Albizia coriaria

Cytotoxic acacic acid glycosides from the roots of Albizia coriaria

  • J Nat Prod. 2009 Oct;72(10):1725-30. doi: 10.1021/np900126r.
Olivier Placide Noté 1,  Anne-Claire Mitaine-Offer,  Tomofumi Miyamoto,  Thomas Paululat,  Jean-François Mirjolet,  Olivier Duchamp,  Dieudonné Emmanuel Pegnyemb,  Marie-Aleth Lacaille-Dubois
Affiliations

Affiliation

  • 1 Laboratoire de Pharmacognosie, UMIB, EA 3660, Faculté de Pharmacie, Université de Bourgogne, 7 Boulevard Jeanne D'Arc, BP 87900, 21079 Dijon Cedex, France.
PMID: 19778067 DOI: 10.1021/np900126r
Abstract

Two new oleanane-type saponins, coriariosides A (1) and B (2), along with a known saponin, gummiferaoside C (3), were isolated from the roots of Albizia coriaria. Their structures were established by extensive analysis of 1D and 2D NMR experiments (COSY, ROESY, TOCSY, HSQC, and HMBC) and mass spectrometry. Compounds 1 and 3 when tested for cytotoxicity against two colorectal human Cancer cells showed activity against the HCT 116 (IC50 4.2 microM for 1 and 2.7 microM for 3) and HT-29 (IC50 6.7 microM for 1 and 7.9 microM for 3) cell lines.

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