2. Academic Validation
  3. Novel lead for potent inhibitors of breast cancer resistance protein (BCRP)

Novel lead for potent inhibitors of breast cancer resistance protein (BCRP)

  • Bioorg Med Chem Lett. 2010 Jan 1;20(1):180-3. doi: 10.1016/j.bmcl.2009.11.004.
Anne Pick 1,  Henrik Müller,  Michael Wiese
Affiliations

Affiliation

  • 1 Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany.
PMID: 19932960 DOI: 10.1016/j.bmcl.2009.11.004
Abstract

From our modulator library an interesting inhibitor of breast Cancer resistance protein (BCRP) was identified. Due to its high inhibitory potency, this compound may serve as a promising novel lead for the design of new and potent modulators. This adds a new structural class to the few known highly active BCRP inhibitors.

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