2. Academic Validation
  3. Actiketal, a new member of the glutarimide antibiotics

Actiketal, a new member of the glutarimide antibiotics

  • J Antibiot (Tokyo). 1991 Feb;44(2):160-3. doi: 10.7164/antibiotics.44.160.
T Sonoda 1,  H Osada,  J Uzawa,  K Isono
Affiliations

Affiliation

  • 1 RIKEN Institute of Physical and Chemical Research, Saitama, Japan.
PMID: 2010356 DOI: 10.7164/antibiotics.44.160
Abstract

A new glutarimide Antibiotic named actiketal was isolated from the culture fluid of the epiderstatin-producing streptomycete, Streptomyces pulveraceus subsp. epiderstagenes. The IC50 of the Antibiotic for inhibition of the incorporation of [3H]thymidine into epidermal growth factor-stimulated Balb/MK cells was 14.5 microM. The structure of this compound was determined by 1H and 13C NMR spectroscopic analyses using 1H-1H COSY, 13C-1H COSY, heteronuclear multiple-bond correlation spectroscopy, selective 13C-[1H] NOE's techniques.

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