2. Academic Validation
  3. Macagigantin, a farnesylated flavonol from Macaranga gigantea

Macagigantin, a farnesylated flavonol from Macaranga gigantea

  • J Asian Nat Prod Res. 2009 Nov;11(11):929-32. doi: 10.1080/10286020903302315.
Mulyadi Tanjung 1,  Euis H Hakim,  Didin Mujahidin,  Muhammad Hanafi,  Yana M Syah
Affiliations

Affiliation

  • 1 Organic Chemistry Division, Institut Teknologi Bandung, Bandung, Indonesia.
PMID: 20183255 DOI: 10.1080/10286020903302315
Abstract

A new farnesylated flavonol derivative, macagigantin (1), together with two known Flavonoids, glyasperin A (2) and apigenin (3), had been isolated from the acetone extract of the leaves of Macaranga gigantea. The structure of the new compound was elucidated as 6-farnesylkaempferol based on its spectroscopic data, including UV, IR, 1D and 2D NMR, and HR-EI-MS spectra. Compounds 1-3 were evaluated for their cytotoxic properties against P-388 cells, their IC(50) values being 11.3, 6.0, and 5.1 microM, respectively.

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