2. Academic Validation
  3. Water-soluble PDE4 inhibitors for the treatment of dry eye

Water-soluble PDE4 inhibitors for the treatment of dry eye

  • Bioorg Med Chem Lett. 2010 May 1;20(9):2928-32. doi: 10.1016/j.bmcl.2010.03.023.
Steven P Govek 1,  Guy Oshiro,  John V Anzola,  Clay Beauregard,  Jasmine Chen,  Avery R Coyle,  Daniel A Gamache,  Mark R Hellberg,  Jennifer N Hsien,  Julia M Lerch,  John C Liao,  James W Malecha,  Lena M Staszewski,  David J Thomas,  John M Yanni,  Stewart A Noble,  Andrew K Shiau
Affiliations

Affiliation

  • 1 Kalypsys, Inc., 10420 Wateridge Circle, San Diego, CA 92121, United States. sgovek@san.rr.com
PMID: 20378348 DOI: 10.1016/j.bmcl.2010.03.023
Abstract

PDE4 inhibitors have the potential to alleviate the symptoms and underlying inflammation associated with dry eye. Disclosed herein is the development of a novel series of water-soluble PDE4 inhibitors. Our studies led to the discovery of coumarin 18, which is effective in a rabbit model of dry eye and a tear secretion test in rats.

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