2. Academic Validation
  3. Cytotoxic ent-kaurane diterpenoids from Isodon rubescens var. lushiensis

Cytotoxic ent-kaurane diterpenoids from Isodon rubescens var. lushiensis

  • J Nat Prod. 2010 Jun 25;73(6):1112-6. doi: 10.1021/np100110u.
Xiao Luo 1,  Jian-Xin Pu,  Wei-Lie Xiao,  Yong Zhao,  Xue-Mei Gao,  Xiao-Nian Li,  Hai-Bo Zhang,  Yuan-Yuan Wang,  Yan Li,  Han-Dong Sun
Affiliations

Affiliation

  • 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
PMID: 20521771 DOI: 10.1021/np100110u
Abstract

Ten new ent-kaurane Diterpenoids, isolushinins A-J (1-10), together with 20 known compounds, were isolated from the aerial parts of Isodon rubescens var. lushiensis. The structures of 1-10 were elucidated by spectroscopic analysis. Several of the compounds isolated were evaluated for their cytotoxicity against the HL-60, SMMC-7721, A-549, SK-BR-3, and PANC-1 human Cancer cell lines, and some exhibited quite potent inhibitory activities.

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