2. Academic Validation
  3. Cytotoxic triterpenoid glycosides from the roots of Gordonia chrysandra

Cytotoxic triterpenoid glycosides from the roots of Gordonia chrysandra

  • J Nat Prod. 2009 May 22;72(5):866-70. doi: 10.1021/np900089v.
Lei Yu 1,  Jing-Zhi Yang,  Xiao-Guang Chen,  Jian-Gong Shi,  Dong-Ming Zhang
Affiliations

Affiliation

  • 1 Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Ministry of Education, Beijing 100050, People's Republic of China.
PMID: 20560647 DOI: 10.1021/np900089v
Abstract

Eight new oleanane triterpenoid glycosides, gordonosides A-H (1-8), were isolated from a 50% EtOH extract of the roots of Gordonia chrysandra. Their structures were determined by spectroscopic analysis, including 1D and 2D NMR and ESIMS, and by chemical methods. Among these substances, compounds 1, 3, 5, and 6 exhibited cytotoxic activity against several human Cancer cell lines, with 3 being the most potent.

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