2. Academic Validation
  3. Morroniside cinnamic acid conjugate as an anti-inflammatory agent

Morroniside cinnamic acid conjugate as an anti-inflammatory agent

  • Bioorg Med Chem Lett. 2010 Aug 15;20(16):4855-7. doi: 10.1016/j.bmcl.2010.06.095.
Yoshinori Takeda 1,  Naomi Tanigawa,  Fortunatus Sunghwa,  Masayuki Ninomiya,  Makoto Hagiwara,  Kenji Matsushita,  Mamoru Koketsu
Affiliations

Affiliation

  • 1 Department of Chemistry, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
PMID: 20621474 DOI: 10.1016/j.bmcl.2010.06.095
Abstract

A morroniside cinnamic acid conjugate was prepared and evaluated on E-selectin mediated cell-cell adhesion as an important role in inflammatory processes. 7-O-Cinnamoylmorroniside exhibited excellent anti-inflammatory activity (IC(50)=49.3 microM) by inhibiting the expression of E-selectin; further, it was more active than another cinnamic-acid-conjugated iridoid glycoside (harpagoside; IC(50)=88.2 microM), 7-O-methylmorroniside, and morroniside itself. As a result, 7-O-cinnamoylmorroniside was observed to be a potent inhibitor of TNF-alpha-induced E-selectin expression.

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