2. Academic Validation
  3. Synthesis and biological evaluation of new jasplakinolide (jaspamide) analogs

Synthesis and biological evaluation of new jasplakinolide (jaspamide) analogs

  • Bioorg Med Chem Lett. 2010 Sep 1;20(17):5104-7. doi: 10.1016/j.bmcl.2010.07.023.
Arun K Ghosh 1,  Zachary L Dawson,  Deuk Kyu Moon,  Ruoli Bai,  Ernest Hamel
Affiliations

Affiliation

  • 1 Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA. akghosh@purdue.edu
PMID: 20678932 DOI: 10.1016/j.bmcl.2010.07.023
Abstract

Synthesis and biological evaluation of jasplakinolide analogs are described. The synthesis of analogs utilized a diastereoselective syn-aldol reaction and an orthoester Claisen rearrangement as key steps. All synthetic analogs were evaluated for their ability to disrupt the actin Cytoskeleton. Compounds 2, 3, and 4 essentially displayed similar activity to jasplakinolide.

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