2. Academic Validation
  3. Antiproliferative effects of saponins from the roots of Platycodon grandiflorum on cultured human tumor cells

Antiproliferative effects of saponins from the roots of Platycodon grandiflorum on cultured human tumor cells

  • J Nat Prod. 2010 Nov 29;73(11):1863-7. doi: 10.1021/np100496p.
Yeon Hee Choi 1,  Dae Seok Yoo,  Mi-Ran Cha,  Chun Whan Choi,  Young Sup Kim,  Sang-Un Choi,  Kang Ro Lee,  Shi Yong Ryu
Affiliations

Affiliation

  • 1 Korea Research Institute of Chemical Technology, Taejeon 305-343, Korea.
PMID: 20939516 DOI: 10.1021/np100496p
Abstract

Three new triterpenoid saponins, platyconic acid B lactone (1), deapio-platyconic acid B lactone (2), and deapio-platycodin D(2) (3), together with 17 known triterpenoid saponins, were isolated from a root extract of Platycodon grandiflorum. The structures of 1-3 were determined on the basis of spectroscopic data interpretation and chemical transformation. Saponins with a platycodigenin or polygalacic acid unit as a sapogenin demonstrated significant inhibitory effects on the proliferation of a small panel of cultured human tumor cells.

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