2. Academic Validation
  3. N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)(phenyl)amino]propyl}benzamide analogs as potent Kv1.3 inhibitors. Part 1

N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)(phenyl)amino]propyl}benzamide analogs as potent Kv1.3 inhibitors. Part 1

  • Bioorg Med Chem Lett. 2010 Dec 1;20(23):6983-8. doi: 10.1016/j.bmcl.2010.09.132.
Curt D Haffner 1,  Stephen A Thomson,  Yu Guo,  Lee T Schaller,  Sharon Boggs,  Scott Dickerson,  Jeff Gobel,  Dan Gillie,  J Patrick Condreay
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, GlaxoSmithKline Research and Development, Research Triangle Park, NC 27709, USA. curt.d.haffner@gsk.com
PMID: 20971642 DOI: 10.1016/j.bmcl.2010.09.132
Abstract

We report the synthesis and in vitro activity of a series of novel N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)(phenyl)amino]propyl}benzamide analogs. These analogs showed potent inhibitory activity against Kv1.3. Several compounds, including compound 8b, showed similar potency to the known Kv1.3 inhibitor PAP-1 when tested under the IonWorks patch clamp assay conditions.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z