1. Academic Validation
  2. NF kappa B inhibitors and antitrypanosomal metabolites from endophytic fungus Penicillium sp. isolated from Limonium tubiflorum

NF kappa B inhibitors and antitrypanosomal metabolites from endophytic fungus Penicillium sp. isolated from Limonium tubiflorum

  • Bioorg Med Chem. 2011 Jan 1;19(1):414-21. doi: 10.1016/j.bmc.2010.11.012.
Amal H Aly 1 Abdessamad Debbab Carol Clements Ruangelie Edrada-Ebel Barbora Orlikova Marc Diederich Victor Wray Wenhan Lin Peter Proksch
Affiliations

Affiliation

  • 1 Heinrich-Heine-Universität, Institut für Pharmazeutische Biologie und Biotechnologie, Universitätsstrasse 1, Geb. 26.23, D-40225 Düsseldorf, Germany. amal.hassan@uni-duesseldorf.de
Abstract

Chemical investigation of the endophytic fungus Penicillium sp. isolated from Limonium tubiflorum growing in Egypt afforded four new compounds of polyketide origin, including two macrolides, penilactone (1) and 10,11-epoxycurvularin (2), a dianthrone, neobulgarone G (7), and a sulfinylcoumarin, sulfimarin (14), along with twelve known metabolites (3-6, 8-13, 15 and 16). The structures of all compounds were assigned by comprehensive spectral analysis (1D and 2D NMR) and mass spectrometry. Compounds 3, 4, 13 and 16 showed pronounced antitrypanosomal activity with mean MIC values ranging from 4.96 to 9.75μM. Moreover, when tested against a panel of three human tumor cell lines compounds 3, 4, 6 and 12 showed selective growth inhibition against Jurkat and U937 cell lines with IC(50) values ranging from 1.8 to 13.3μM. The latter compounds also inhibited TNFα-induced NF-κB activity in K562 cells with IC(50) values ranging from 1.6 to 10.1μM, respectively.

Figures