2. Academic Validation
  3. Discovery of non-glucoside SGLT2 inhibitors

Discovery of non-glucoside SGLT2 inhibitors

  • Bioorg Med Chem Lett. 2011 Apr 15;21(8):2472-5. doi: 10.1016/j.bmcl.2011.02.056.
An-Rong Li 1,  Jian Zhang,  Joanne Greenberg,  TaeWeon Lee,  Jiwen Liu
Affiliations

Affiliation

  • 1 Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA. anrongl@amgen.com
PMID: 21398124 DOI: 10.1016/j.bmcl.2011.02.056
Abstract

A series of benzothiazinone and benzooxazinone derivatives were discovered as SGLT2 inhibitors. The optimization led to the discovery of compounds 31 and 32, which exhibited similar potency and better SGLT1 selectivity compared to dapagliflozin. These compounds may provide novel promising scaffolds, which are different from phlorizin-based SGLT2 inhibitors.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z