2. Academic Validation
  3. Synthesis and biological activity of 22-deoxo-23-oxa analogues of saponin OSW-1

Synthesis and biological activity of 22-deoxo-23-oxa analogues of saponin OSW-1

  • J Med Chem. 2011 May 12;54(9):3298-305. doi: 10.1021/jm101648h.
Jadwiga Maj 1,  Jacek W Morzycki,  Lucie Rárová,  Jana Oklest'ková,  Miroslav Strnad,  Agnieszka Wojtkielewicz
Affiliations

Affiliation

  • 1 Institute of Chemistry, University of Białystok , Piłsudskiego 11/4, 15-443 Białystok, Poland.
PMID: 21438635 DOI: 10.1021/jm101648h
Abstract

Analogues of the potent cytotoxic saponin OSW-1 were prepared from the readily available steroidal 16β,17α,22-triol. The new 22-deoxo-23-oxa analogues of OSW-1 were screened against eight Cancer cell lines and normal human fibroblasts. The analogues proved to be slightly less active than OSW-1 but also less toxic to normal cells. They induce concentration- and time-dependent Apoptosis of mammalian Cancer cells with Caspase-3 activation.

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